Vacant Positions

Announcement of vaccancies within the GOLD project
Announcement of job vaccancies in other projects/laboratories

Announcement of vaccancies within the GOLD project

Freie Stellen für DiplomandInnen an der Technischen Universität Graz
Diplomarbeit am Institut für Genomik und Bioinformatik in der Arbeitsgruppe Juliane Bogner-Strauss zu vergeben

Hintergrund:
Weltweit leiden zurzeit gleich viele Menschen an Unterernährung wie an Übergewicht. Übergewicht zieht viele Erkrankungen nach sich, wie Diabetes, erhöhtes Risiko für Herzinfarkt, Schlaganfall, Unfruchtbarkeit, Bluthochdruck, Arthritis, etc. Fettleibigkeit ist inzwischen nicht nur ein gesundheitliches sondern auch ein wirtschaftliches Problem.

Aktuelle Themen: Funktionelle Untersuchung von Genen, die eine Rolle im Fettstoffwechsel spielen.

Arbeitstechniken: Klonieren von Genen, sowie deren Knock-down oder Überexpression in verschiedenen humanen und murinen Zellmodellen und folgende Analyse (Zellfärbemethoden & -Fraktionierung, qPCR, Western Blot, Dünnschichtchromatographie). Eventuell Arbeiten mit Mäusen (wenn erwünscht).

Weitere Informationen unter Diplomarbeit.

Bei Interesse kurz vorher anrufen, um einen Gesprächstermin zu vereinbaren.

Assoc. Prof. Mag. Dr. Juliane Bogner-Strauss
Email: juliane.bogner-strauss@tugraz.at
Tel: + 43 316-873-5337
Mobil: + 43-664-5221766

Technische Universität Graz
Institut für Genomik und Bioinformatik
Petersgasse 14/V, 8010 Graz

http://genome.tugraz.at

This thesis offer was posted on Apr 17, 2012

Announcement of job vaccancies in other projects and laboratories

PostDoc Position at the Departments of Human Biology and Movement Sciences, Maastricht University
PostDoc Position (2-4 years)

The Muscle Metabolism and Diabetes Research Group of Profs. Schrauwen and Hesselink focuses on the normal regulation of human energy and substrate metabolism, including human brown adipose tissue, and on the mechanisms that lead to the development of skeletal muscle insulin resistance and type 2 diabetes mellitus. To this end, whole-body, tissue and cellular approaches are applied, mainly in human studies but also in rodent and cellular models. Maastricht University has unique facilities to perform human translational studies, and a new Metabolic Research Unit has recently been opened, including clamp facilities, magnetic resonance spectroscopy and whole body respiration chambers.

The postdoc will be primarily involved in cellular studies, including studies with human primary myocytes. Cultured myocytes from detailed characterized type 2 diabetic patients, obese controls and healthy subjects (either trained or untrained) will be investigated with regards to lipid droplet dynamics, mitochondrial function and insulin sensitivity. Gene knockdown and overexpression will be applied to study genes of interest. Studying the AMPK-SIRT1-PGC1 pathway – and effects of nutritional compounds hereon - will be a special focus.

Next to skeletal muscle metabolism, cellular studies towards the capacity of human white and brown adipocyte precursors to differentiate into functional brown adipocytes are currently being performed in our laboratory.

For recent work of The Muscle Metabolism and Diabetes Research Group, please see:

  • Bosma, M., Kersten, S., Hesselink, M.K.C., Schrauwen, P. Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity. Prog Lipid Res, 51 (1), 36-49, 2012.
  • Timmers, S., Konings, E., Bilet, L., Houtkooper, R.H., van de Weijer, T., Goossens, G.H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Moonen-Kornips, E., Hesselink, M.K.C., Kunz, I., Schrauwen-Hinderling, V.B., Blaak, E.E., Auwerx, J., Schrauwen, P. Cell Metabolism, 14, 612-622, 2011.
  • Hoeks, J., Mensink, M., Hesselink, M.K.C., Ekroos, K., Schrauwen, P. Long- and medium-chain fatty acids induce insulin resistance to a similar extent in humans despite marked differences in muscle fat accumulation. JCEM, 97 (1), 208-216, 2012.
  • Marken Lichtenbelt, W.D. van., Vanhommerig, J.W., Smulder, N.M., Drossaerts, J.M.A.F.L., Kemerink, G.J.J. Schrauwen, P., Teule, G.J.J. Cold-activated brown adipose tissue in healthy adults. NEJM, 360 (15), 1500-1508, 2009.

For a more detailed job description please download PostDoc_Position.pdf and contact Patrick Schrauwen at p.schrauwen@maastrichtuniversity.nl

This PostDoc Position offer was posted on Apr 10, 2012.

PostDoc Position in Singapore
PostDoc Position to study Molecular Mechanisms of Lipid Metabolism

A postdoctoral research fellow position is available to study the biochemical mechanisms of triglyceride lipid droplet (LD) formation. Understanding LD formation is relevant to developing treatments for obesity-associated diseases such as type 2 diabetes. David Silvers group has recently identified Fat storage-Inducing Transmembrane (FITM1/FIT1 & FITM2/FIT2) proteins as important in the process of LD formation.

Projects include biochemical characterization of FIT protein function and analysis of physiological and pathophysiological function in mouse models of FIT protein deficiency.

Candidates holding a Ph.D. degree and having fluency in molecular biology, protein biochemistry and in working with mouse models are encouraged to apply.

Duke-NUS has developed a new state-of-the-art biomedical research facility that benefits from close access to specialized research facilities at both the National University of Singapore and the Biopolis at A*STAR.

Please visit http://www.duke-nus.edu.sg/web/ for more details!

Applicants should email a CV and names and contact information of three references to david.silver@duke-nus.edu.sg

For a more detailed job description download PostDoc Position.pdf

This PostDoc Position offer was posted on Feb 21, 2012.

 

 

If you wish to post an announcement concerning the GOLD project please contact Caroline Schober-Trummler.

last updated 17.04.2012